Publications
All our publications can be found on CSIC repository: https://digital.csic.es
Authors: Elisa del Barrio Cortés, Clara Matutano Molina, Luis Rodríguez-Lorenzo, Nieves Cubo-Mateo
TITLE: Generation of Controlled Micrometric Fibers inside Printed Scaffolds Using Standard FDM 3D Printers
REF. Polymers, 15(1), 96
Clave A: DOI: https://doi.org/10.3390/polym15010096
URI: http://hdl.handle.net/10261/285973
Authors: Itziar González, Jon Luzuriaga, Alba Valdivieso, Jesús Frutos, Luis Hernández, Luis Rodríguez-Lorenzo, Virginia Yagüe, José Luis Blanco, Julie Earl
TITLE: Low-intensity continuous ultrasound to inhibit cancer cell migration
REF. Front. Cell Dev. Biol. Volume 10, 2022; PUBLISHED 12 January 2023
Clave A: DOI: https://doi.org/10.3389/fcell.2022.842965
URI: http://hdl.handle.net/10261/286927
Authors: Luis Hernández–Álvarez, Carlos Negreira, Antonio Ramos, Luis M. Rodríguez, Nieves Cubo Mateo, Alberto Pinto del Corral, Icíar González Gómez
TITLE:Analysis of the angular influence in the spatial study of mechanical displacements in highly anisotropic media
REF. Mechanics of Materials. Volume 163, December 2021, 104094
DOI: https://doi.org/10.1016/j.mechmat.2021.104094
URI: http://hdl.handle.net/10261/252164
​
Authors: A.C. Hernández-González, L. Téllez-Jurado; Luis M Rodríguez-Lorenzo
TITLE:PREPARATION OF COVALENTLY BONDED SILICA-ALGINATE HYBRID
HYDROGELS BY SCHIFF BASE AND SOL-GEL REACTIONS
REF. Carbohydrate polymers 267 (2021). 118186; https://doi.org/10.1016/j.carbpol.2021.118186
http://hdl.handle.net/10261/240351
​​
Authors: Raúl Rosales-Ibáñez, Nieves Cubo-Mateo, Amairany Rodríguez-Navarrete, Arely M González-González, Tomás E Villamar-Duque, Leticia O Flores-Sánchez, Luis M Rodríguez-Lorenzo
TITLE: Assessment of a PCL-3D printing-Dental Pulp Stem Cells triplet for bone engineering
REF. Polymers 2021, 13(7), 1154; DOI: https://doi.org/10.3390/polym13071154
URI: http://hdl.handle.net/10261/236626
​
Authors: A.C. Hernández-González, L. Téllez-Jurado; Luis M Rodríguez-Lorenzo
TITLE: Synthesis of in situ silica-alginate hybrid hydrogels by a sol-gel route
REF. Carbohydrate polymers 250, 2020, #116877 DOI: https://doi.org/10.1016/j.carbpol.2020.116877; http://hdl.handle.net/10261/218692
​
Authors: Nieves Cubo-Mateo, L.M. Rodríguez-Lorenzo
TITLE: Design of Thermoplastic 3D-Printed Scaffolds for Bone Tissue Engineering: Influence of Parameters of “Hidden” Importance in the Physical Properties of Scaffolds REF. REVISTA/LIBRO Polymers 2020, 12, 1546; DOI:10.3390/polym12071546; http://hdl.handle.net/10261/216708
​
Authors: D.A. Sánchez-Téllez, L.M. Rodríguez-Lorenzo, L. Téllez-Jurado
TITLE: Siloxane-Inorganic Chemical Crosslinking of 1 Hyaluronic Acid – Based Hybrid
Hydrogels: Structural Characterization
REF. REVISTA/LIBRO Carbohydrate polymers. 230, Año 2020, #115590
DOI: https://doi.org/10.1016/j.carbpol.2019.115590; URI: http://hdl.handle.net/10261/194187
​
Authors: Aurora C. Hernández-González, Lucia Téllez-Jurado; Luis M Rodríguez-Lorenzo
TITLE: Alginate hydrogels for bone tissue engineering, from injectables to bioprinting: A Review. REF. REVISTA/LIBRO Carbohydrate polymers 229, Año 2020, # 115514
doi: 10.1016/j.carbpol.2019.115514; URI: http://hdl.handle.net/10261/193039
​
Authors: M. Gómez-Ballesteros, V. Andrés-Guerrero, F. J. Parra, J. Marinich, B. de-las-Heras, I. T. Molina-Martínez, B. Vázquez-Lasa, J. San Román, R. Herrero-Vanrell.
TITLE: Amphiphilic Acrylic Nanoparticles Containing the Poloxamer Star Bayfit®10WF15 as Ophthalmic Drug Carriers
REF. REVISTA/LIBRO: Polymers, (11), 1213 (2019)
DOI: 10.3390/polym11071213
​
Authors: G. Azuara, J. García-García, B. Ibarra, F. J. Parra-Ruiz, A. Asúnsolo, M. A. Ortega, B. Vázquez-Lasa, J. Buján, J. San Román, B. de la Torre
TITLE: Estudio experimental de la aplicación de un nuevo cemento óseo cargado con antibióticos de amplio espectro para el tratamiento de la infección ósea
REF. REVISTA/LIBRO: Revista Española de Cirugía Ortopédica y Traumatología, (63),95-103 (2019)
DOI: 10.1016/j.recot.2018.10.002
​
Authors: Daniela A Sánchez-Téllez; Lucia Téllez-Jurado; Luis M Rodríguez-Lorenzo
Title: Hydrogels for cartilage regeneration, from polysaccharides to hybrids
REF. Polymers, Vol 9 (12), 2017 pp. 671; doi:10.3390/polym9120671, http://hdl.handle.net/10261/158123
​
Authors. D.M. González, L Téllez-Jurado, R. Jiménez-Gallegos, Luis M. Rodríguez-Lorenzo,
TITLE: Novel non-cytotoxic, bioactive and biodegradable hybrid materials based on polyurethanes/TiO2 for biomedical applications
REF. MATERIAL SCIENCE AND ENGINEERING C; Vol 75, año 2017, pp 375-384 DOI: 10.1016/j.msec.2017.02.041
​
Authors: J Quintana Plaza, L Benito-garzón, B Bravo Giménez, B Fernández-Montes Moraleda, F Collía, Luis M. Rodríguez-Lorenzo
Title: Application of calcium phosphates and fibronectin as complementary treatment for osteoporotic bone fractures
REF. Injury 47S3: 2016, p.p. S13–S19http://dx.doi.org/10.1016/S0020-1383(16)30601-5
​
Authors: B Fernández-Montes Moraleda, J San Román, Luis M. Rodríguez-Lorenzo,
Title: Adsorption and conformational modification of fibrinogen and fibronectin adsorbed on Hydroxyapatite. A QCM-D study
REF. J Biomed Mater Res A. Vol 104(10) 2016, pp 2585-2594 DOI: 10.1002/jbm.a.35802
​
Authors: Belén Fernández-Montes Moraleda, J San Román, Luis M. Rodríguez-Lorenzo,
Title: Influence of surface features of hydroxyapatite on the adsorption of proteins relevant to bone regeneration.
REF. J Biomed Mater Res A. Vol: 101 (8); 2013, pp. 2332-2339 DOI: 10.1002/jbm.a.34528
​
Authors: Luis M. Rodriguez-Lorenzo, Laura Saldaña, Lorena Benito-Garzón, Raul García-Carrodeguas, Salvador de Aza, Nuria Vilaboa, Julio San Román
Title: Feasibility of ceramic-polymer composite cryogels as scaffolds for bone tissue engineering.
REF. J Tissue Eng Reg Med. Vol 6; 2012, pp 421-433 DOI: 10.1002/term.443
SYNTHESIS OF IN-SITU SILICA-ALGINATE HYBRID HYDROGELS BY A SOLGEL ROUTE
by: Aurora C. Hernández-González; Lucía Téllez-Jurado; Luis M. Rodríguez-Lorenzo
The preparation of silica-alginate hybrid hydrogels by a sol-gel route is proposed in this work. The in-situ synthesis of silica networks from tetraethoxysilane (TEOS) and aminopropyltriethoxysilane (APTES) precursors in an alginate matrix is assayed. The experimental parameters were analyzed in three consecutive stages to obtain hybrid materials with specific properties. Stage 1: effect of water and catalyst ratios. Stage 2: effect of the inorganic precursor’s ratio. Stage 3: effect of concentration of the alginate solution. The hydrolysis-condensation reactions of the silica precursors were regulated by the alginate concentration, the silica precursor nature, and the HCl/inorganic/H2O ratio. Hybrids prepared with both silica precursors generate longer silica chains. High alginate amounts increase the storage modulus of synthesized hybrids, and high catalyst ratios reduce their stability. Compositions with alginate content of 5 and 8 (wt/v)%, TEOS/APTES weight ratio of 74/26, and without catalyst are suitable to evaluation for their application in tissue engineering.
Design of Thermoplastic 3D-Printed Scaffolds for Bone Tissue Engineering: Influence of Parameters of “Hidden” Importance in the Physical Properties of Scaffold
By: Nieves Cubo-Mateo; Luis M. Rodríguez-Lorenzo
Additive manufacturing (AM) techniques are becoming the approaches of choice for the construction of scaffolds in tissue engineering. However, the development of 3D printing in this field brings unique challenges, which must be accounted for in the design of experiments. The common printing process parameters must be considered as important factors in the design and quality of final 3D-printed products. In this work, we study the influence of some parameters in the design and fabrication of PCL scaffolds, such as the number and orientation of layers, but also others of “hidden” importance, such as the cooling down rate while printing, or the position of the starting point in each
layer. These factors can have an important impact on the final porosity and mechanical performance of the scaffolds. A pure polycaprolactone filament was used. Three different configurations were selected for the design of the internal structure of the scaffolds: a solid one with alternate layers(solid) (0, 90), a porous one with 30% infill and alternate layers (ALT) (0, 90) and a non-alternated configuration consisting in printing three piled layers before changing the orientation (n-ALT) (0, 0, 0, 90, 90, 90). The nozzle temperature was set to 172 C for printing and the build plate to 40 C. Strand diameters of 361 26 m for room temperature cooling down and of 290 30 m for forced cooling down, were obtained. A compression elastic modulus of 2.12 0.31 MPa for n-ALT and 8.58 0.14 MPa for ALT scaffolds were obtained. The cooling down rate has been observed as an important parameter for the final characteristics of the scaffold.
Hydrogels for Cartilage Regeneration, from Polysaccharides to Hybrids
by: Daniela Anahí Sánchez-Téllez, Lucia Téllez-Jurado, Luis M. Rodríguez-Lorenzo
The aims of this paper are: (1) to review the current state of the art in the field of cartilage substitution and regeneration; (2) to examine the patented biomaterials being used in preclinical and clinical stages; (3) to explore the potential of polymeric hydrogels for these applications and the reasons that hinder their clinical success. The studies about hydrogels used as potential biomaterials selected for this review are divided into the two major trends in tissue engineering: (1) the use of cell-free biomaterials; and (2) the use of cell seeded biomaterials. Preparation techniques and resulting hydrogel properties are also reviewed. More recent proposals, based on the combination of different polymers and the hybridization process to improve the properties of these materials, are also reviewed. The combination of elements such as scaffolds (cellular solids), matrices (hydrogel-based), growth
factors and mechanical stimuli is needed to optimize properties of the required materials in order to facilitate tissue formation, cartilage regeneration and final clinical application. Polymer combinations and hybrids are the most promising materials for this application. Hybrid scaffolds may maximize cell growth and local tissue integration by forming cartilage-like tissue with biomimetic features.
Alginate hydrogels for bone tissue engineering, from injectables to bioprinting: A review
by: Aurora C. Hernández-González; Lucía Téllez-Jurado; Luis M. Rodríguez-Lorenzo
This review focuses on recently developed alginate injectable hydrogels and alginate composites for applications in bone tissue regeneration, and it evaluates the alternatives to overcome the problems that avoid their utilization in the field. Section 2 covers the properties of alginates that have made them useful for medical applications, in particular their ionic gelling ability for preparing injectable compositions used as delivery drugs systems. The advantages and shortcomings of these preparations are revised together with the chemical modifications assayed. Section 3 describes how it has been taken advantage of alginates into the new field of biofabrication and the developments in bone engineering. The state of the art of this field is reviewed. Finally in Section 4, new developments and approaches that in opinion of the authors can lead to a breakthrough in bone tissue engineering using alginates are introduced.